Patterns of surface temperature response to various agents.

Surface temperature response to 15 agents was studied at 20 C. and 55 per cent humidity. Toe temperature was considered representative of the body's "glomus area." Temperatures at forehead and cheek represented the "blush area." Diethylaminoethanol, Hydergine, tetraethylammonium chloride, Priscoline, hexamethonium, Ilidar and Dibenzyline produced a prompt rise in temperature in the glomus area without affecting the temperature in the blush area; nicotinic acid, Roniacol, histamine and papaverine caused the opposite response. Nitroglycerin had no effect on the temperature in the blush area; with the subject recumbent, it caused a fall in the glomus area. Hypertonic saline, aminophylline and Banthine had no effect on either glomus or blush areas.